�Scientific American magazine focused on two University of Alabama at Birmingham (UAB) Comprehensive Cancer Center researchers in a news story on observational next-generation anticancer therapies.
David T. Curiel, M.D., Ph.D., is a UAB professor of medicine and director of the human gene therapy division, and Ronald Alvarez, M.D., is a UAB professor of medicine and director of the gynecologic oncology division.
Both doctors ar featured in a Scientific American particular cancer edition, and both served as co-authors on the account "Tumor-busting viruses." The editors chose Curiel and Alvarez because of their research into a field call viral factor therapy, or virotherapy.
Virotherapy involves an experimental technique to target viruses to genus Cancer cells spell leaving levelheaded cells unaffected. The viruses are genetically engineered to kill tumor cells in different ways. One means is by adopting the viruses' natural ability to invade and reproduce as a way to deliver target genes that make tumor cells more susceptible to existing chemotherapies.
Curiel and Alvarez have been testing this concept with a virus compound called adenovirus in women with repeated ovarian or other gynecologic cancers. The clinical trial is noneffervescent in the early stages, yet the compound has shown antitumour effects that appear secure to most patients, Curiel said.
"We foresee a strong role for viruses that is, curative viruses in 21st-century medicament," Curiel and Alvarez wrote in wrote in the story.
First proposed in the 1940s, virotherapy now relies heavily on adenoviruses, a cause of the common cold that has been studied and altered extensively for medical research. Adenoviruses have the ability to shuttle targeted segments of DNA into a tumor cell and make biochemical changes that minimize damage to good for you cells.
University of Alabama at Birmingham
701 20th St. S, AB 1320
Birmingham, AL 35294-0113
United States
http://www.uab.edu
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Tuesday 2 September 2008
Wednesday 13 August 2008
`Dark Knight' stays on top with $26M
LOS ANGELES �
Batman was higher than Hollywood's newest bay window heads.
"The Dark Knight" took in $26 million to finish as the No. 1 picture for the fourth straight weekend, beating the stoner comedy "Pineapple Express," which opened in second
Wednesday 6 August 2008
'Watchmen' Scenes Of War, Murder And Transformation Draws Thunderous Response At Comic-Con
SAN DIEGO — If day unitary of Comic-Con belonged to "Twilight," then the sec afternoon, still filled with scantily clad Leias and obese Batmen, was the realm of "Watchmen." A comic book holy grail for 3 decades, the Alan Moore/ Dave Gibbons masterpiece is the only if graphic novel ever to win skill fiction's honored Hugo Award and the only comic to appear in Time magazine's list of the greatest novels of the 20th century. This supposedly unfilmable flux of ism, theology and heroism has caused such names as Gilliam, Aronofsky and Greengrass to throw their custody up in disgust.
But on Friday — one year after
Thursday 26 June 2008
Wednesday 18 June 2008
Metronomy announce one-off London show
Metronomy have announced a one-off London show, set to take place in July.
The group, led by songwriter and multi-instrumentalist Joseph Mount, will play Camden's Barfly on July 2.
The gig comes shortly before Metronomy release their new single 'Holiday' on July 7.
The band's album 'Nights Out', a concept record about going out, is set to be released on September 8.
To check the availability of Metronomy tickets and get all the latest listings, go to NME.COM/GIGS now, or call 0871 230 1094.
The group, led by songwriter and multi-instrumentalist Joseph Mount, will play Camden's Barfly on July 2.
The gig comes shortly before Metronomy release their new single 'Holiday' on July 7.
The band's album 'Nights Out', a concept record about going out, is set to be released on September 8.
To check the availability of Metronomy tickets and get all the latest listings, go to NME.COM/GIGS now, or call 0871 230 1094.
Monday 9 June 2008
Matchbox twenty's guitarist steps in front of the microphone with new band
LOS ANGELES - Paul Doucette's experience as one part of the hugely successful matchbox twenty taught him a little something about the break and repair method of music-making.
Not too long ago, Doucette along with other band mates wondered if matchbox twenty would have a future. After years of friction, the band took an extended hiatus with some wondering if they would ever regroup.
It was during that time Doucette put together the group The Break and Repair Method, stepping in front of the microphone as their lead songwriter and singer.
"It was a product of definitely being in a band and being in a band where I wasn't a songwriter," Doucette said in an interview announcing both the band and its new album. "It was an experiment: What do I sound like on my own?"
The result, he says, is "milk the bee," the anticipated debut album from The Break and Repair Method set to be released this fall. The first single, "You Won't Be Able To Be Sad," drops later this month.
It's an album, Doucette says, that almost didn't make it after going through three different labels before finding a home with bluhammock music.
"The title came out of that frustration: Putting out a record is like milking a bee. It's pointless," he said.
It's an album that appears also to have been born out of musical frustration.
"It kind of started as a mine, mine, mine thing," he said.
It has since grown to include a number of musicians and singers, including his wife Moon Zappa, who sings on several tracks.
A first listen to the album reveals that is a musical departure from matchbox twenty.
From the first single to the last song, recently added, "The City (Is Bound To Do Us In)," Doucette's affinity for dark lyrics set to upbeat melodies is evident. But it's his sometimes bluesy, gravelly vocals that drive it home.
Doucette says he doesn't expect to have an explosive solo career, like matchbox's lead singer Rob Thomas.
"I don't expect people to go 'Oh, he's in matchbox. I love his record,' " he said. "They don't know me. They know me as matchbox twenty."
Since the completion of "milk the bee," Doucette has been making music again with his friends in what some may call a repaired matchbox twenty. He also switched roles in the band, moving from drummer to rhythm guitarist to replace Adam Gaynor, who left the band.
"One of the things that helped us on the matchbox thing is that we all went off and did our own thing," he said.
Doucette said matchbox plans to reunite to put out another album some time in 2009. In the meantime, he plans to tour with The Break and Repair Method.
"In an ideal world, I'll be going back and forth between the two," he said. "That's a good problem to have."
And by the way, he has since learned people really do milk bees. It's a term used to describe the extraction of bee venom.
See Also
Sunday 1 June 2008
Waveshape
Artist: Waveshape
Genre(s):
Other
Discography:
Vestige
Year: 1999
Tracks: 6
Wellenformen
Year: 1996
Tracks: 6
Zyklus
Year: 1995
Tracks: 12
Polychron
Year: 1994
Tracks: 7
Sigma
Year: 1993
Tracks: 7
Nicolas Cage - Bollywood Firm Invests In Stars Companies
Saturday 24 May 2008
The Apprentice - Sara Fired From The Apprentice For Bludgeoning Sales
Trained barrister Sara Dhada was fired from The Apprentice after her sales technique failed in a wedding-related task.
The 25-year-old car saleswoman was accused of using a "bludgeoning" sales approach as her team attempted to sell wedding products at a bridal fair in Birmingham.
Dhada was joined in the boardroom by Michael Sophocles - for the second week running - and Helene Speight, whose team had been beaten to the tune of nearly £4,000 by Lucinda Ledgerwood's team.
Speight's decision as team leader to sell mid-range wedding dresses at the Birmingham event had proved costly with Ledgerwood's team making some £5,752.99 profit through their successful sales of high-end dresses and lingerie.
And though Sophocles was again criticised by Sir Alan Sugar on the BBC1 reality show, it was Dhada who got the boot, with the Amstrad boss accusing her of "alienating" brides to be with her sales tactics.
"If I had been one of those recipients of your sales pitch I would've got your head and pushed it in the bloody cake," he told her.
"You go off like a machine gun. You have a tendency of transmitting and not receiving. You talk, talk, talk but don't listen," he added.
Dhada, from Leicester, said her experience on the fourth series of the show had taught her that she needs "to defend herself".
"I need to say 'you can't speak to me like that'," she continued.
"I didn't defend myself properly. I was so tired. I was thinking just let Sir Alan say what he's got to say, get it over and done with."
15/05/2008 08:22:16
See Also
Sunday 11 May 2008
Sunday 4 May 2008
More awards for Oscar-tipped Atonement
More awards for Oscar-tipped Atonement
Period drama 'Atonement' has picked up another legion of awards in advance of the Oscars.
It received iV prizes at the inauguration Richard Attenborough Film Awards: Best Film, Filmmaker of the year for director Joe Wright, Player of the Year for Henry James McAvoy and Film writer of the Class for Christopher Lionel Hampton.
'Atonement' star Keira Knightley missed out on the Best Actress award, which went or else to Cate Blanchett for 'Elizabeth: The Golden Age'.
Surface-to-air missile Riley was named Revolt Lead of the Year for his breakthrough functioning as Pleasure Division frontman Ian William Curtis in 'Control'.
At the ceremony, host Richard Attenborough said: "The last class has shown picture palace to be both resilient and innovative, with boastfully audiences bore to enjoy the unique theatrical have."
He added: "It has besides brought a superb harvest of terrific films with compelling performances from both experienced and new talents. I offer my warmest congratulation to this admirable set of winners."
'Atonement', an adaptation of Ian McEwan's bestselling novel, has been nominated for seven Oscars, including Best Pic and Best Support Actress for 13-year-old Irish people actress Saoirse Ronan.
It is in rivalry for 14 awards at the BAFTAs, which will drive piazza on Sun 10 Feb.
Tuesday 29 April 2008
Thursday 24 April 2008
Monday 21 April 2008
DJ Quicksilver
Artist: DJ Quicksilver
Genre(s):
Trance
Dance
Discography:
Clubfiles
Year: 2003
Tracks: 13
Always On My Mind
Year: 2002
Tracks: 14
Escape 2 Planet Love
Year: 1998
Tracks: 12
Quicksilver
Year: 1997
Tracks: 10
By
Garmarna
Thursday 17 April 2008
Les Negresses Vertes
Artist: Les Negresses Vertes
Genre(s):
Pop
Discography:
Acoustic Clubbing
Year: 2001
Tracks: 14
Mlah
Year: 1988
Tracks: 14
Taking a punk-like approach to a miscellany of Latin, rai, and folk music, Les Negresses Vertes create an infectuous dance music. Ab initio comprised of family members, friends and lovers, Les Negresses Vertes has come a foresightful way since their earliest performances. Although most members of the band didn't play an tool until advent together in late-1987, the amply grown has continued to evolve into a selfsame exciting support players.
Les Negresses Vertes' climb to world-wide success has not come easy. On January 22, 1993, the group's lyrist, Christmastime Rota, best known as "Helno" and "Helno Rota De Lourcqua," died spell attempting to get the c. H. Best a severe do drugs addiction. Rota's twin familiar, Ritter Thierry, continues to perform with Haine Et Ses Amours. Since Rota's end, guitarist/vocalist Stefane Mellion and accordionist/vocalist Matthias Canavese, as well known as Canavese and Matias, keep fictive his part in the front logical argument of Les Negresses Vertes. A native of Algeria, Mellion has lived in Paris since the early-1980s. During the hexad long time before the band was formed, he spent his summers working in his parent 's sportfishing net income business endeavour and played with bands in Paris the rest of the twelvemonth. The youngest phallus of Les Negresses Vertes, Canavese hereditary practically of his talent from his father of the Christian church, a manual manual laborer world Health Organization became an amusement promoter at the eld of 40 and forthwith directs a genus Circus school. Although he trained as an acrobat, he was forced to seek other avenues of side next an chance event. Other members of Les Negresses Vertes let in guitar participant, bassist and vocaliser, Jean-Marie Paulus, trumpet and tombone player and singer Abraham Sirinix and pianist, guitar musician and vocaliser Jo Roz.
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